What type of tumor is associated with Call-Exner bodies?

Call-Exner bodies are distinctive histological structures typically associated with granulosa-theca cell tumors, which are a type of sex-cord stromal tumor of the ovary. These structures are characterized by small, round, eosinophilic structures resembling immature Graafian follicles that contain a granular, basophilic material.

Granulosa-theca cell tumors are known for their production of estrogen and can often lead to symptoms related to elevated estrogen levels, such as abnormal uterine bleeding or changes in secondary sexual characteristics. The presence of Call-Exner bodies is a diagnostic hallmark, helping to differentiate granulosa cell tumors from other types of ovarian neoplasms.

This association underlines the importance of recognizing specific histopathological features when diagnosing tumors, which can significantly impact patient management.