What type of tumor shows pseudopalisading tumor cells on biopsy?

Pseudopalisading tumor cells are a characteristic histological feature observed in glioblastoma multiforme, which is an aggressive type of brain tumor. In glioblastomas, unlike other tumors, the cells are arranged in a pattern that appears as though they are palisading around areas of necrosis. This is due to the tumor's rapid growth outpacing its blood supply, leading to central areas of ischemic necrosis. The adjacent cells then accumulate and align peripherally around these necrotic zones, creating the distinctive pseudopalisading appearance.

This histological pattern helps pathologists distinguish glioblastoma multiforme from other types of brain tumors, as tumors such as meningiomas, neuroblastomas, and astrocytomas do not typically exhibit this specific arrangement of tumor cells around necrotic areas. Instead, they present with other histological features pertinent to their respective tumor types. Thus, the identification of pseudopalisading cells is a crucial diagnostic indicator for glioblastoma multiforme.