Where does benign prostatic hyperplasia typically occur?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Benign prostatic hyperplasia (BPH) most commonly occurs in the transitional zone of the prostate. This zone surrounds the urethra and is primarily composed of glandular tissue that can undergo hyperplastic changes. As BPH occurs in this area, it leads to the enlargement of prostate tissue, which can compress the urethra, causing common urinary symptoms such as increased frequency of urination, urgency, and difficulty starting or stopping urination.

Understanding the anatomy of the prostate is essential to comprehend where BPH develops. The prostate is anatomically divided into several zones: the peripheral zone, central zone, transitional zone, and anterior fibromuscular stroma. BPH specifically arises from the transitional zone, making it distinct from other prostate conditions such as prostate cancer, which generally originates in the peripheral zone.

In summary, the transitional zone of the prostate is where benign prostatic hyperplasia typically occurs, leading to characteristic obstructive urinary symptoms due to the enlargement of this specific area surrounding the urethra.

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