Where is GLUT2 predominantly expressed?

GLUT2, a member of the glucose transporter family, plays a crucial role in glucose homeostasis and is characterized by its high capacity and low affinity for glucose. It is predominantly expressed in certain key tissues involved in glucose metabolism and regulation.

In the context of its primary locations, GLUT2 is notably found in hepatocytes (liver cells), where it facilitates glucose uptake and release to and from the bloodstream, playing a vital role in gluconeogenesis and glycogenolysis. It is also present in pancreatic beta cells, where it helps in sensing blood glucose levels and regulating insulin secretion in response to varying blood glucose concentrations. In the kidney, GLUT2 is involved in the reabsorption of glucose from the renal tubular fluid, while in the small intestine, it aids in glucose absorption from digested food.

This specific distribution allows GLUT2 to effectively participate in major metabolic processes, making it essential for maintaining glucose levels in the body. It is not predominantly expressed in skeletal muscle and adipose tissue, which primarily utilize GLUT4, nor is it primarily found in neurons or the placenta, where other glucose transporters are more active. Hence, the description of GLUT2's expression in hepatocytes, pancreatic beta cells, kidney, and small intestine is accurate