Which autoimmune disorder is characterized by a butterfly facial rash and Raynaud's phenomenon in young females?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Systemic lupus erythematosus (SLE) is the autoimmune disorder characterized by a butterfly facial rash and Raynaud's phenomenon, particularly in young females. This condition is multi-faceted and can affect various organ systems, leading to widespread inflammation and damage.

The butterfly rash, or "malar rash," typically appears across the cheeks and nose and is a classic cutaneous manifestation of SLE. It is often triggered or exacerbated by sun exposure, which is also a feature associated with this disease. Raynaud's phenomenon, where the fingers and toes exhibit episodic vasospasm leading to color changes and sensations of coldness or numbness, is also commonly observed in SLE patients due to vascular involvement.

SLE predominantly affects younger women, particularly those of childbearing age, which aligns with the demographic specified in the question. Its diverse clinical manifestations and systemic nature necessitate a comprehensive approach for diagnosis and management, further reinforcing its distinction from other autoimmune disorders.

Rheumatoid arthritis primarily affects joints, scleroderma involves skin and internal organs with distinct features, and dermatomyositis presents with muscle weakness and skin lesions, which are different from the specific signs associated with SLE. Hence, systemic lupus erythematosus is

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