Which cancer is associated with Epstein-Barr virus (EBV)?

Burkitt's lymphoma is notably associated with Epstein-Barr virus (EBV). This particular type of non-Hodgkin lymphoma is characterized by high proliferation rates of B-lymphoid cells and is most commonly found in children and young adults. The pathogenetic mechanism involves the translocation of the MYC oncogene, often in the setting of a pre-existing EBV infection, which plays a crucial role in lymphocyte transformation and proliferation, particularly in endemic cases that are seen in Africa.

EBV also has a strong link with Hodgkin's lymphoma, where it can be found in Reed-Sternberg cells, but Burkitt's lymphoma is specifically recognized for its direct association with EBV, especially in its endemic form. The marked association with EBV in Burkitt's lymphoma highlights the virus's impact on oncogenesis in B-cell malignancies.

The other cancers listed do not have a significant association with EBV. For instance, multiple myeloma primarily arises from plasma cells without an established connection to EBV. Chronic lymphocytic leukemia is a type of leukemia that generally does not involve EBV in its pathogenesis. Therefore, Burkitt's lymphoma stands out as the cancer most directly linked to Epstein-B