Which cancer is Neuro Specific Enolase (NSE) a marker for?

Neuro Specific Enolase (NSE) is an enzyme that is primarily found in neurons and neuroendocrine cells. It serves as a marker for neuroendocrine tumors, making it particularly relevant in the context of certain types of cancers. Neuroblastoma, which is a common pediatric malignant tumor derived from neural crest tissue, often elevates levels of NSE. This is due to the tumor's neuroblastic origin, which promotes the production of this enzyme.

While NSE can sometimes be elevated in small cell lung carcinoma due to its neuroendocrine characteristics, it is most specifically associated with neuroblastoma in the context of pediatric tumors. NSE is utilized in the diagnosis and monitoring of neuroblastoma, assisting clinicians in assessing disease progression or response to treatment.

In summary, NSE is closely linked to neuroblastoma, signifying its value as a biomarker in this particular cancer type.