Which cancer type is likely to metastasize to the kidney?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Testicular carcinoma is known for its propensity to metastasize to various organs, including the kidneys. The spread of testicular cancer often follows the lymphatic drainage patterns and can result in distant metastases to sites such as the lungs, liver, and sometimes the kidneys. This is particularly relevant for germ cell tumors, which are the most common type of testicular cancer. They can disseminate via lymphatics and hematogenously, leading to renal involvement.

In contrast, while other cancer types listed can also metastasize, they are less commonly associated with renal metastasis compared to testicular carcinoma. For instance, hepatocellular carcinoma tends to spread to the lungs and bone rather than the kidneys. Rectal carcinoma can metastasize primarily to the liver and lungs through hematogenous routes. Thyroid carcinoma usually has a more predictable spread pattern but does not typically lead to renal metastasis. Therefore, testicular carcinoma stands out as the cancer most likely to metastasize to the kidneys.

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