Which cancers are most likely to metastasize to the liver?

The liver is one of the most common sites for metastasis due to its rich blood supply and its role in the venous drainage of the gastrointestinal (GI) tract and other tissues. Certain cancers have a higher propensity to spread to the liver.

Gastric cancer, for instance, often spreads to the liver as it can invade adjacent tissues and is also associated with a high incidence of metastasis. The blood supply of the stomach is directly connected to the hepatic portal circulation, providing a pathway for cancer cells to travel from the stomach to the liver.

Lung cancer is also notorious for liver metastases. The lungs are a highly vascularized organ, and tumors that arise in the lungs can spread hematogenously (via the bloodstream) to the liver. This tendency is driven by the high cellular turnover and aggressive nature of many lung malignancies.

In contrast, while cancers such as breast, kidney, prostate, thyroid, ovarian, and cervical are also capable of metastasis, they do not commonly target the liver as frequently as gastric and lung cancers do, making option B the most plausible answer for cancers most likely to metastasize to the liver.