Which cells are primarily responsible for producing fibrinogen and C-reactive protein during inflammation?

The primary cells responsible for producing fibrinogen and C-reactive protein (CRP) during inflammation are hepatocytes. These liver cells play a crucial role in the acute phase response, which is a part of the body's systemic reaction to inflammation. When inflammation occurs, pro-inflammatory cytokines (particularly interleukin-6) stimulate the liver to synthesize and secrete various acute phase proteins, including fibrinogen and CRP.

Fibrinogen is essential for blood clotting, as it is converted to fibrin during the coagulation process. CRP serves as a marker of inflammation and has roles in the immune response, including opsonization of pathogens, thereby promoting their clearance.

The involvement of hepatocytes in this context highlights the liver's integral role in managing systemic inflammation and responding to injury. This function is a key aspect of the body's innate immune system and underscores the connection between the liver and inflammatory processes.