Which condition can lead to bowel obstruction and has a genetic predisposition?

Peutz-Jeghers syndrome is a genetic condition characterized by the development of multiple hamartomatous polyps in the gastrointestinal tract, as well as mucocutaneous pigmentation. One of the significant complications associated with Peutz-Jeghers syndrome is bowel obstruction, which can occur due to the presence of these polyps. The polyps, if they become oversized or if they lead to intussusception (a condition where a part of the intestines telescopes into another segment), can obstruct the intestinal lumen, causing bowel obstruction.

This syndrome is inherited in an autosomal dominant fashion, emphasizing the genetic predisposition aspect of the question. Individuals diagnosed with this syndrome have a higher lifetime risk for developing various malignancies, particularly in the gastrointestinal tract, but the immediate concern in the context of bowel obstruction makes Peutz-Jeghers syndrome the most fitting choice.

Other conditions like familial adenomatous polyposis, Crohn's disease, and ulcerative colitis also can lead to bowel issues, but they are not primarily characterized by the development of polyps that lead to obstruction in the same way that Peutz-Jeghers syndrome does, nor do they have the same distinctive genetic inheritance pattern related to bowel obstruction specifically.