Which condition is characterized by pitting edema and a flaky, paint-like dermatitis?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The condition characterized by pitting edema and a flaky, paint-like dermatitis is indeed Kwashiorkor. This condition typically arises from a severe deficiency of protein in the diet, despite the potential for adequate caloric intake. The edema results from low levels of serum albumin, which disrupts oncotic pressure in the blood vessels, leading to fluid accumulation in the interstitial spaces.

The skin changes observed in Kwashiorkor often include flaky dermatitis. This type of dermatitis presents as a dry, scaly, and sometimes discolored skin, which can appear in a cracked or flaky texture, resembling peeling paint. These dermatological manifestations stem from the lack of essential nutrients and are often accompanied by other signs such as hair discoloration and changes in hair texture.

Other options, while they may involve nutritional components or other systemic issues, do not specifically present with both pitting edema and the distinctive flaky dermatitis that is characteristic of Kwashiorkor. For instance, Marasmus primarily results in weight loss and muscle wasting due to extreme malnutrition but does not typically cause significant edema or the specific skin changes seen in Kwashiorkor. Hyperthyroidism can lead to a range of symptoms including changes in skin quality, but it is not associated with the condition

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