Which condition is characterized by monoclonal gammopathy and is commonly associated with bone pain or fractures?

Multiple myeloma is a hematologic malignancy characterized by the proliferation of monoclonal plasma cells in the bone marrow, leading to monoclonal gammopathy. Patients with multiple myeloma often present with symptoms related to the destructive effects of the neoplastic plasma cells on the skeleton. This condition is notably associated with bone pain, which can be caused by osteolytic lesions and an increased risk of fractures due to weakened bone structure.

The presence of excess monoclonal immunoglobulin in the serum can lead to other complications as well, including renal impairment or hyperviscosity syndrome, but the hallmark clinical manifestations often include significant bone involvement. This differentiates multiple myeloma from the other conditions listed, which do not have the same prominence of skeletal symptoms combining with monoclonal gammopathy.

While chronic lymphocytic leukemia may present with lymphadenopathy and other hematologic abnormalities, it is not primarily characterized by bone pain related to monoclonal gammopathy. Waldenstrom's macroglobulinemia is more associated with hyperviscosity and lymphoplasmacytic infiltration but does not typically cause the extensive bone pain or lesions seen in multiple myeloma. Plasmacytoma, while also related to monoclon