Which condition is incorrectly diagnosed if a patient presents with lytic lesions and a rash?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Multiple myeloma is characterized by the proliferation of malignant plasma cells in the bone marrow, which often leads to the development of lytic bone lesions, hypercalcemia, renal dysfunction, and anemia. Although some patients with multiple myeloma can experience skin changes due to related conditions or infections, the presence of a rash is not a classical manifestation of this disease.

In contrast, adult T-cell leukemia (a type of T-cell lymphoma) can present with lytic bone lesions and a skin rash as part of its clinical picture, typically due to leukemic infiltration of tissues and associated conditions. Acute myeloid leukemia generally does not present with lytic bone lesions or rashes as prominent features; rather, it is primarily characterized by acute symptoms related to bone marrow failure, such as anemia, infection, and bleeding. Chronic lymphocytic leukemia also does not typically manifest with lytic bone lesions or rashes; it mainly presents with lymphadenopathy, splenomegaly, and peripheral blood lymphocytosis.

Therefore, while multiple myeloma is indeed associated with lytic lesions, the clinical picture of a rash alongside these lesions suggests a different underlying process, making multiple myeloma an incorrect diagnosis in this scenario.

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