Which condition is inherited in an autosomal dominant manner and involves a deficiency in LDL receptors?

Familial hypercholesterolemia is inherited in an autosomal dominant manner and is characterized by a deficiency in low-density lipoprotein (LDL) receptors. This condition leads to elevated levels of LDL cholesterol in the bloodstream, increasing the risk of atherosclerosis and cardiovascular disease.

In familial hypercholesterolemia, the defect is primarily in the LDL receptors which are essential for the clearance of LDL particles from the circulation. When these receptors are deficient or dysfunctional, LDL cholesterol cannot be efficiently removed from the blood, leading to its accumulation. This genetic disorder can manifest with premature coronary artery disease, tendon xanthomas, and arcus corneae.

The other conditions mentioned do not have the same inheritance pattern or mechanism. Abetalipoproteinemia is a recessive disorder involving a defect in the apolipoprotein B, leading to the inability to properly transport fats in the body. Familial lipoprotein lipase deficiency is also inherited in an autosomal recessive manner and involves a deficiency in lipoprotein lipase, leading to chylomicron accumulation. Familial dysbetalipoproteinemia is associated with a defect in the apolipoprotein E and is typically also inherited in an autosomal recess