Which demonstrates a stronger genetic predisposition?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Diabetes Mellitus type 2 demonstrates a stronger genetic predisposition compared to type 1. The heritability of type 2 diabetes is significantly high, with numerous studies indicating that individuals with a family history of type 2 diabetes have an increased risk of developing the disease themselves. Genetic factors contribute to insulin resistance, beta-cell dysfunction, and the overall metabolic syndrome associated with type 2 diabetes, making it more prevalent in certain populations with genetic risk factors.

In contrast, type 1 diabetes is primarily an autoimmune condition characterized by the destruction of insulin-producing beta-cells in the pancreas. While there is a genetic component to type 1 diabetes, such as associations with specific HLA (human leukocyte antigen) genes, its heritability is lower than that of type 2. Environmental factors such as viral infections and diet also play a significant role in triggering the onset of type 1 diabetes, which introduces more variability compared to the predominantly genetic influences seen in type 2 diabetes.

Given these points, the stronger genetic predisposition associated with type 2 diabetes makes it the correct answer in this context.

Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy