Which disease is indicated by the presence of large lysosomal vesicles in phagocytes?

Chediak-Higashi disease is characterized by the presence of large lysosomal vesicles in phagocytes, which results from a genetic defect affecting lysosomal trafficking. This disease is associated with mutations in the LYST gene (lysosomal trafficking regulator), leading to impaired fusion of lysosomes with phagosomes. As a result, the normal function of phagocytes, such as effectively engulfing and destroying pathogens, is compromised. The accumulation of these enlarged lysosomal vesicles can lead to immune deficiencies, increased susceptibility to infections, and other systemic manifestations, including albinism and neurological issues.

The other conditions listed do not primarily involve the accumulation of large lysosomal vesicles in phagocytes. Sarcoidosis primarily presents with granuloma formation in various organs, Tay-Sachs disease is a neurological disorder caused by the deficiency of the enzyme hexosaminidase A, leading to the accumulation of GM2 gangliosides in the brain, and alpha-1 antitrypsin deficiency is a genetic disorder that results in lung and liver problems due to a deficiency of the alpha-1 antitrypsin protein. Thus, the distinct characteristic of large lysosomal vesicles in phagocytes specifically points to Chediak-Hig