Which endocrine change is associated with aging and leads to carbohydrate intolerance?

Carbohydrate intolerance associated with aging is primarily due to reduced insulin receptors. As individuals age, there is a tendency for the number and functionality of insulin receptors to decrease. This reduction leads to impaired insulin signaling, which in turn can result in decreased glucose uptake by the cells. As insulin becomes less effective, the body's ability to manage blood glucose levels diminishes, leading to carbohydrate intolerance.

In addition to reduced insulin receptors, aging is often accompanied by other metabolic changes, such as increased adiposity and alteration in hormone levels, which can further exacerbate insulin resistance. However, the specific connection to aging and its direct impact on carbohydrate metabolism is most clearly illustrated by the reduction in insulin receptor quantity and efficiency. This understanding is crucial for recognizing how aging influences metabolic health and the risk of developing conditions like type 2 diabetes.