Which issue can result from age-related musculoskeletal changes?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

As individuals age, various musculoskeletal changes occur that can significantly impact bone health. The skeletal system undergoes changes in density and structure, often leading to conditions such as osteoporosis. This loss of bone density makes bones more fragile and more susceptible to fractures, even with minimal trauma or stress.

Additionally, age-related changes in the musculoskeletal system include the deterioration of cartilage, weakening of tendons, and a general decline in the regenerative capacity of tissues. These factors contribute to an increased risk of fractures as the bones become less able to withstand the normal loads they encounter during daily activities.

In contrast, increased flexibility is generally associated with younger ages; hyperplasia of muscle fibers is not a typical change with aging and is more relevant in conditions like hypertrophy from exercise or disease; and the reduction of ligament elasticity does occur as well, but it typically leads to joint stability issues rather than direct fractures. Therefore, the most direct and common consequence of age-related musculoskeletal changes is an increased risk of fractures due to compromised bone integrity.

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