Which lymphoma is linked to the c-myc activation due to a specific chromosomal translocation?

Burkitt's lymphoma is specifically associated with the activation of the c-myc oncogene due to a characteristic chromosomal translocation, typically t(8;14). This translocation places the c-myc gene on chromosome 8 adjacent to the immunoglobulin heavy chain locus on chromosome 14, leading to overexpression of the c-myc protein. This overexpression results in uncontrolled cellular proliferation, which is a hallmark of Burkitt's lymphoma.

Burkitt's lymphoma is a highly aggressive form of non-Hodgkin's lymphoma, often presenting in children and young adults, frequently affecting the jaw or abdomen. The presence of c-myc activation is a critical factor in its pathogenesis and helps distinguish it from other types of lymphomas. The rapid growth and tendency to present with advanced disease are typical, making early diagnosis and treatment essential.

This link between c-myc activation and Burkitt's lymphoma illustrates the role of chromosomal translocations in oncogenesis and highlights the importance of understanding molecular mechanisms in the classification and treatment of lymphomas.