Which markers are classically positive in Reed-Sternberg cells?

Reed-Sternberg cells, which are characteristic of Hodgkin lymphoma, are identified by specific surface markers that aid in their diagnosis. These abnormal cells typically express CD15 and CD30, which are crucial in differentiating them from other lymphoid cells.

CD15 is a carbohydrate antigen that plays a role in cell adhesion, while CD30, a member of the TNF receptor family, is involved in proliferation and survival signals. The presence of these markers is essential for confirming the diagnosis of Hodgkin lymphoma, as they are not commonly found in other lymphomas or hematological malignancies.

Other markers, such as CD45, CD20, CD3, CD4, CD19, and CD22, are generally associated with different types of lymphocytes or hematological malignancies, rather than Reed-Sternberg cells. Understanding these specific markers helps in the effective classification and diagnosis of lymphoproliferative disorders.