Which medication is used for treating liver hypnozoites in malaria?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The correct medication for treating liver hypnozoites in malaria is primaquine. This drug specifically targets the dormant liver stages of Plasmodium vivax and Plasmodium ovale, which are the two malaria species known to have a hypnozoite stage that can cause relapses of the disease. Primaquine works by interfering with the mitochondrial function in these stages, leading to their elimination.

Chloroquine is primarily used to treat the blood stages of malaria infections caused by all species of Plasmodium but does not have any activity against liver hypnozoites. Statins and warfarin are not used in the treatment of malaria; statins are cholesterol-lowering agents, while warfarin is an anticoagulant used to prevent blood clots. Thus, primaquine is the only agent listed that effectively addresses the quiescent liver forms, preventing relapse and thereby reducing the overall disease burden.

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