Which monoclonal gammopathy is associated with macroglossia, mucocutaneous lesions, carpal tunnel, and/or hepatomegaly?

The condition associated with macroglossia, mucocutaneous lesions, carpal tunnel syndrome, and/or hepatomegaly is indeed amyloidosis. In this disorder, an accumulation of abnormal proteins, known as amyloid, occurs in various tissues and organs, leading to the symptoms mentioned.

Macroglossia arises because amyloid deposits can infiltrate the tongue, causing it to enlarge. Mucocutaneous lesions can also result from amyloid deposits, and they may present as purpura or other skin changes. Carpal tunnel syndrome is another common manifestation, often due to the deposition of amyloid in the carpal tunnel, leading to compression of the median nerve. Hepatomegaly can be seen as the liver also becomes infiltrated with amyloid, resulting in organ enlargement and potential dysfunction.

In contrast, multiple myeloma primarily presents with bone pain, anemia, renal failure, and hypercalcemia due to the proliferation of monoclonal plasma cells and associated bone lesions. Plasmacytoma is localized, often manifesting as a solitary bone lesion or soft tissue mass, and does not typically cause systemic symptoms like macroglossia or carpal tunnel syndrome. Waldenstrom's macroglobulinemia