Which of the following diseases is associated with HLA-DR3?

HLA-DR3 is a major histocompatibility complex (MHC) molecule that has been strongly linked to certain autoimmune diseases. Among the listed options, type I diabetes mellitus is particularly associated with HLA-DR3. This association highlights the genetic predisposition for the disease, where individuals carrying this specific HLA subtype may have an increased risk of developing antibodies against their own pancreatic beta cells, ultimately leading to the destruction of insulin-producing cells.

In the context of other conditions mentioned, while celiac disease is commonly associated with HLA-DQ2 and HLA-DQ8 rather than HLA-DR3, and multiple sclerosis has a more established connection with HLA-DR2, fibromyalgia lacks a specific genetic HLA association. The association of HLA-DR3 with type I diabetes underscores the complex interplay of genetic susceptibility and environmental factors in the development of autoimmune conditions. Thus, the correct response relating to HLA-DR3 is type I diabetes mellitus.