Which of the following is a common neoplasm in children?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Acute lymphoblastic leukemia (ALL) is indeed a common neoplasm in children and is characterized by the rapid proliferation of lymphoblasts in the bone marrow and peripheral blood. It typically presents in children between the ages of 2 and 5 years and accounts for about 20-30% of all childhood cancers. The high incidence of ALL in pediatric populations is attributed to the biological behavior of lymphoid tissues during childhood, which is particularly susceptible to malignant transformations.

The cells involved in ALL are lymphoid progenitor cells that undergo malignant transformation due to various genetic changes, which can include translocations and mutations. This neoplasm can lead to symptoms such as anemia, bleeding due to thrombocytopenia, and increased susceptibility to infections.

Other neoplasms mentioned, while they do occur in children, are either less common than ALL or have a different demographic distribution. Hodgkin lymphoma, while it does occur in children, is more frequently seen in adolescents. Rhabdomyosarcoma is a soft tissue sarcoma that, although it is one of the more common soft tissue tumors in children, still occurs at a lower rate than ALL. Neuroblastoma, which typically arises from neural crest cells and commonly affects infants and toddlers, is also notable

Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy