Which of the following is a known complication of hemochromatosis?

Hemochromatosis, a condition characterized by excessive iron accumulation in the body, is known to lead to several complications due to the toxic effects of iron on various organs. One of the most significant complications associated with hemochromatosis is the increased risk of hepatocellular carcinoma.

Patients with hemochromatosis are particularly susceptible to liver disease due to iron deposition in liver tissue, leading to conditions such as liver cirrhosis. Cirrhosis is a known precursor to liver cancer, and the chronic inflammation and cellular turnover associated with cirrhosis facilitate the development of malignancies. The presence of excessive iron enhances oxidative stress and can cause DNA damage, further promoting oncogenesis.

Thus, individuals with untreated or poorly managed hemochromatosis have an elevated risk of developing hepatocellular carcinoma, making this option the most relevant and appropriate answer in the context of complications related to the condition.