Which of the following is not a characteristic of cervical dysplasia?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Cervical dysplasia is a precursor to cervical cancer characterized by abnormal cellular changes in the squamous epithelial cells of the cervix. One of the hallmark features of cervical dysplasia is the presence of koilocytic changes, which are indicative of human papillomavirus (HPV) infection. Koilocytic changes involve the appearance of perinuclear cytoplasmic vacuolization and atypical nuclei.

Nuclear enlargement and hyperchromasia are also significant characteristics observed in dysplastic cells. Nuclear enlargement refers to an increase in the size of the nucleus relative to the cytoplasm, while hyperchromasia denotes an increased staining intensity of the nucleus due to a higher amount of DNA, both of which reflect increased cellular activity and potential malignancy.

Ground-glass nuclei, while a feature observed in some other conditions, such as certain viral infections or specific neoplastic processes, are not typically associated with cervical dysplasia. In cervical dysplasia, the described characteristics primarily revolve around nuclear and cytoplasmic abnormalities indicative of HPV-induced changes. Therefore, ground-glass nuclei are not a characteristic of cervical dysplasia, distinguishing it from the other options, which are indeed associated with this condition.

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