Which of the following tumors is associated with increased serotonin levels?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The correct answer to the question about tumors associated with increased serotonin levels is that all of the listed tumors can be related to elevated serotonin.

Bronchial carcinoid tumors are well-known for their capacity to produce serotonin, which can lead to the development of carcinoid syndrome if they metastasize and if the serotonin levels become sufficiently high. This syndrome is characterized by flushing, diarrhea, and bronchoconstriction.

Small cell carcinoma of the lung, also known as small cell lung cancer (SCLC), can produce various neuroendocrine substances, including serotonin. Although this is not the most common associated hormone, it is still recognized that some SCLCs can lead to increased serotonin levels.

Medullary carcinoma of the thyroid arises from parafollicular C cells, which can secrete calcitonin and, in some cases, other neuroendocrine substances, potentially including serotonin. While not as common as in the other two types, it can still lead to elevated levels.

Thus, recognizing that all listed tumors can be associated with increased serotonin levels supports the conclusion that option D is correct.

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