Which organism is known to be sensitive to novobiocin?

Staphylococcus epidermidis is known to be sensitive to novobiocin, which is an important characteristic that helps differentiate it from other coagulase-negative staphylococci, particularly Staphylococcus saprophyticus. Novobiocin sensitivity is used clinically to identify Staphylococcus epidermidis, which is often associated with infections in immunocompromised patients and those with indwelling devices due to its role as a part of the normal skin flora.

Conversely, Staphylococcus saprophyticus is notable for its resistance to novobiocin, which is often tested because it is a common cause of urinary tract infections, especially in young women. Thus, knowing the sensitivity profiles of these organisms is important for appropriate antibiotic treatment strategies. The other organisms listed, Streptococcus pneumoniae and Enterococcus faecalis, are not classified based on novobiocin sensitivity, as this is specific to certain staphylococci.