Which spider bite is known to cause crampy pain in the thighs and abdomen?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The black widow spider is known for its bite that can lead to significant systemic effects, including crampy pain in the thighs and abdomen. This is largely due to the neurotoxic venom it injects, which contains a protein called latrotoxin. This toxin causes the release of neurotransmitters such as acetylcholine and catecholamines, which can lead to a range of symptoms including severe abdominal pain, muscle cramping, and spasms. In fact, the clinical syndrome often referred to as "latrodectism" includes not only pain but also symptoms like rigidity and severe muscle cramps, particularly in the core and lower extremities.

Recognizing the specific pain pattern associated with black widow bites is crucial for diagnosis and management, particularly since the symptoms can mimic other conditions such as appendicitis or acute abdomen. Immediate medical attention is recommended for these bites, especially in at-risk populations such as the elderly or those with underlying health conditions.

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