Which street drug is known to decrease the uptake of dopamine and norepinephrine?

The correct answer is indeed cocaine, as it is known to inhibit the reuptake of dopamine and norepinephrine, leading to increased concentrations of these neurotransmitters in the synaptic cleft. This mechanism enhances their effects on mood, energy levels, and sociability.

Cocaine primarily acts on the dopaminergic system by blocking the dopamine transporter, which is responsible for the reabsorption of dopamine from the synaptic cleft back into the presynaptic neuron. By preventing this reuptake, cocaine markedly increases the availability of dopamine, contributing to its euphoric effects and reinforcing potential for addiction.

In addition to its effects on dopamine, cocaine also affects norepinephrine reuptake, which influences the sympathetic nervous system. This can lead to increased heart rate, heightened alertness, and other physiological responses characteristic of stimulant drugs.

The other substances listed have different mechanisms of action. Heroin primarily interacts with the opioid receptors and has a different impact on neurotransmitter systems. Marijuana's active component, THC, primarily affects cannabinoid receptors and has various effects on mood and cognition but does not primarily focus on reuptake inhibition of dopamine or norepinephrine. MDMA, or ecstasy, influences serotonin release more significantly than dopamine and