Which symptom is indicative of gout or podagra?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The symptom that is indicative of gout, specifically podagra, is pain in the big toe joint. Gout is a type of inflammatory arthritis that occurs due to the deposition of monosodium urate crystals in joints, caused by elevated levels of uric acid in the blood. The metatarsophalangeal joint of the big toe is the most commonly affected site, leading to sudden, severe episodes of pain, swelling, and redness in this joint.

This intense pain often appears at night, and the affected toe can become very sensitive to touch, even the weight of a bed sheet can be excruciating. The characteristic symptom of acute gouty arthritis is the quick onset of pain and inflammation, especially in the big toe, which can serve as a distinguishing feature of gout compared to other types of arthritis.

While swollen finger joints, hard painful nodules, and moist lesions on genitals may be associated with other conditions, they are not specific indicators of gout. Swollen finger joints can be seen in various forms of arthritis, such as rheumatoid arthritis. Hard painful nodules, known as tophi, may develop from chronic gout but represent a more advanced stage of the disease, while moist lesions on genitals do not relate to gout at

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