Which syndrome is associated with multiple colon polyps, osteomas, and impacted or supernumerary teeth?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Gardner's syndrome is characterized by the presence of multiple colon polyps, osteomas, and impacted or supernumerary teeth. This autosomal dominant condition is a variant of familial adenomatous polyposis (FAP), which is primarily known for the development of numerous adenomatous colonic polyps that eventually can lead to colorectal cancer if untreated.

In addition to the colonic polyps seen in Gardner's syndrome, individuals also develop ectopic bone formations, specifically osteomas, which usually manifest in the skull and facial bones. The presence of impacted or supernumerary teeth is a hallmark feature of this syndrome and is due to dental anomalies associated with the condition.

Peutz-Jeghers syndrome, on the other hand, is primarily characterized by hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation, and does not typically include osteomas or dental anomalies. Familial adenomatous polyposis, while related and also causing numerous colon polyps, does not specifically include the osteomas and dental features seen in Gardner's syndrome. Turcot syndrome is characterized by the association of familial colon cancer with central nervous system tumors and does not highlight the specific dental or osteomal manifestations.

Overall, the distinct combination

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