Which syndrome is characterized by recurrent colds, unusual eczema, and high serum IgE levels?

The syndrome characterized by recurrent colds, unusual eczema, and high serum IgE levels is Hyper-IgE syndrome, also known as Job syndrome. This condition is primarily a genetic immunodeficiency that results from mutations affecting the immune system, particularly impacting the function of T-helper cells.

Individuals with Hyper-IgE syndrome often experience recurrent bacterial infections, especially staphylococcal infections, due to impaired antibody production and dysfunction in the immune response. The hallmark traits include eczema, which is a chronic inflammatory skin condition, and significantly elevated levels of serum IgE, often substantially higher than the normal population.

This syndrome can also be associated with skeletal abnormalities, primary teeth retention, and chronic lung disease, all of which reflect the broader implications of immune system dysregulation. Understanding these key features helps in recognizing Hyper-IgE syndrome and differentiating it from other immunodeficiencies or syndromes that might present with some overlapping symptoms.