Which tumor type presents with endodermal sinus structures histology?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Germ cell tumors are the correct answer because they can include various subtypes, one of which is the yolk sac tumor (also known as endodermal sinus tumor). This specific type of germ cell tumor is characterized by the presence of structures resembling the yolk sac, with unique histological features such as Schiller-Duval bodies, which are gland-like structures lined by germ cells and containing mesenchyme, resembling the embryonic yolk sac.

Germ cell tumors can occur in both gonadal (testicular and ovarian) and extragonadal locations, and their histology can exhibit various patterns, but the hallmarks of endodermal sinus structures are associated primarily with the yolk sac tumor subtype. These tumors are known for producing alpha-fetoprotein (AFP), which is a key marker for diagnosis.

Other options, such as Sertoli cell tumors, primarily present with characteristic Sertoli cells but do not demonstrate the unique endodermal sinus structures. Neuroblastoma is a childhood tumor that typically arises from neural crest tissue and has a different histological appearance, often showing small round blue cells. Lastly, gastric adenocarcinoma exhibits glandular formations indicative of epithelial-derived tissues but does not link to any end

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