Which type of bacteria is able to survive without the oxidative burst in Chronic Granulomatous disease?

Chronic Granulomatous Disease (CGD) is a genetic disorder that affects the ability of phagocytes to produce reactive oxygen species (ROS) due to a deficiency in the NADPH oxidase complex. This impairment leads to reduced oxidative burst, compromising the ability of phagocytes to effectively kill certain types of bacteria.

In this context, catalase-positive bacteria, such as Staphylococcus aureus, are able to survive in patients with CGD because they can break down hydrogen peroxide, a byproduct of the immune system's response, into water and oxygen. This enzymatic activity allows them to evade the oxidative damage that normally helps to eliminate bacteria. Consequently, while the neutrophils in individuals with CGD are deficient in producing ROS, the presence of catalase allows these bacteria to survive the innate immune response, which relies heavily on these reactive molecules.

Conversely, catalase-negative bacteria, such as Streptococci and Enterococci, do not possess this protective mechanism and are more susceptible to the immune response even in the absence of an oxidative burst. They cannot decompose hydrogen peroxide and are consequently vulnerable to the effects of this substance that phagocytes release during their attempts to eliminate the infection.

Thus, the ability