Which type of lesion presents as erythroplakia and can lead to squamous cell carcinoma?

Erythroplasia of Queyrat is a precursor lesion characterized by a red, velvety patch found on the glans penis or in other mucosal areas such as the vulva. This lesion is specifically associated with the development of squamous cell carcinoma, particularly in the context of chronic irritation or infection, such as with human papillomavirus (HPV). It represents a carcinoma in situ, meaning that while it exhibits malignant features histologically, it has not yet invaded deeper tissues.

In contrast, Bowen disease is generally represented as a scaly or erythematous patch but is more often associated with skin, particularly on sun-exposed areas. Bowenoid papulosis consists of multiple brownish papules commonly seen on the genital region, again linked with HPV but typically does not progress to invasive carcinoma as frequently as erythroplasia of Queyrat does. Squamous cell carcinoma, while it is the eventual outcome of lesions like erythroplasia of Queyrat if left untreated, is not classified as a precursor lesion itself.

Thus, erythroplasia of Queyrat is distinctly notable for its presentation as erythroplakia and its potential for progression to squamous cell carcinoma.