Which virus is associated with eosinophilic inclusion bodies in hippocampal nerve cells?

Lyssavirus is known to be associated with eosinophilic inclusion bodies, specifically in the context of rabies infection. In cases of rabies, the virus infects neurons and can lead to the formation of Negri bodies, which are eosinophilic cytoplasmic inclusion bodies typically found in the hippocampus and other regions of the brain. These inclusion bodies are indicative of rabies virus replication and viral cytopathogenic effects.

The nucleus of the infected neurons often harbors an abundance of viral particles, and the eosinophilic staining observed under the microscope highlights the viral proteins. This pathological finding is a key feature of rabies infection and helps in the diagnosis of this severe viral encephalitis.

Other viruses mentioned have different associations and pathological findings. For example, adenovirus can lead to atypical inclusions but does not typically present with eosinophilic inclusion bodies in a similar context as Lyssavirus. Influenzavirus primarily affects respiratory tissues and does not produce such specific inclusion bodies, while varicella zoster virus involves different pathological features, particularly in dermal tissues. Thus, Lyssavirus stands out as the correct virus linked with eosinophilic inclusion bodies in the hippocampal nerve cells due to