With which type of lymphoma is "mixed cellularity" associated?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Mixed cellularity is specifically associated with Hodgkin's lymphoma, which is characterized by the presence of various cell types in the tumor microenvironment, including Reed-Sternberg cells. This type of lymphoma often presents with a heterogeneous mixture of lymphoid cells, including lymphocytes, eosinophils, and plasma cells, contributing to the term "mixed cellularity."

In Hodgkin's lymphoma, the mixed cellularity variant is one of several histological subtypes, and it can often present with more advanced disease features. The clinical implications of this subtype typically relate to its presentation and treatment response.

In contrast, other types of lymphoma, such as Non-Hodgkin's lymphoma, Burkitt lymphoma, and lymphoblastic lymphoma, have distinct pathological features and are classified based on different cellular characteristics and patterns. For example, Burkitt lymphoma is known for its very rapid growth and characteristic genetic translocations, while lymphoblastic lymphoma is typically associated with immature lymphoid cells and is often classified as a type of acute lymphoblastic leukemia (ALL) when it presents in the bone marrow. Non-Hodgkin's lymphoma encompasses a broad spectrum of lymphomas that do not fit the profile of Hodgkin’s, meaning they do not have

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